Dr. Lars Lewejohann Institute of Neuro and Behavioural Biology Department of Behavioural Biology University of Muenster Badestrasse 13, D-48149 Muenster Germany Tel.: 0049 251/83 21014 Fax.: 0049 251/83 23896 E-mail: ljohann@phenotyping.com WWW: www.phenotyping.com

Lars Lewejohann (*1970 in Münster) studied Biology and Philosophy at the University of Muenster and finished his diploma thesis in 1999. Subject of his diploma thesis was the evaluation of housing conditions of laboratory mice from an animals' point of view using preference tests. In brief: If mice have the choice, they prefer enriched housing conditions and will even work (pressing a lever up to 16 times per entry) for the access to a more entertaining housing system.
In his PhD-project "Behavioral Phenotyping of Mice: Methods, Evaluation, and Appliance" he investigated BC1-RNA knockout mice by means of a battery of behavioural tests. Tests were carried out with different knockout lines in different laboratories. The combined results indicate that although BC1 RNA does not code any protein, it seems to be involved in the modulation of explorative behaviour.
In order to automate data acquisition, Lars programmed a tracking software using digital image processing techniques (for details on animal tracking, see "Digital Image Processing in Behavioral Sciences"). A list of other valuable software titles can be found on his homepage: www.phenotyping.com. Since 2004 he is working here as a researcher continuing his work with transgenic mice. From 2006 to 2010 Lars also was the managing director of the Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience (OCC), an association for research and education spanning different faculties of the University of Muenster focusing on behavioral neuroscience.

Association for the Study of Animal Behaviour (ASAB)
Deutsche Zoologische Gesellschaft e.V.
Ethologische Gesellschaft e.V.
The International Behavioural and Neural Genetics Society (IBNGS)
Universities Federation for Animal Welfare (UFAW)

Scientific Board
Rodentia - Kleinsäuger Fachmagazin

Publications (including publications in popular press)

• Hundelt, M; Fath, T; Selle, K; Oesterwind, K; Jordan, J; Schultz, C; Götz, J; von Engelhardt, J; Monyer, H; Lewejohann, L; Sachser, N; Bakota, L; Brandt, R (in press): Altered phosphorylation but no neurodegeneration in a mouse model of tau hyperphosphorylation. Neurobiology of Aging.
  
  

• Jansen, F; Heiming, RS; Lewejohann, L; Touma, C; Palme, R; Schmitt, A; Lesch, KP; Sachser, N (2010): Modulation of Behavioural Profile and Stress Response by 5-HTT Genotype and Social Experience in Adulthood. Behavioural Brain Research 207: 21-29.
  
  

• Lewejohann, L; Kloke, V; Heiming, RS; Jansen, F; Kaiser, S; Schmitt, A; Lesch, KP; Sachser, N (2010): Social status and day-to-day behaviour of male serotonin transporter knockout mice. Behavioural Brain Research 211: 80-88.
  
  

• Lewejohann, L; Pickel, T; Sachser, N; Kaiser, S (2010): Wild genius - domestic fool? Spatial learning abilities of wild and domestic guinea pigs. Frontiers in Zoology: 7:9.
  
  

• Ambrée, O; Richter, H; Sachser, N; Lewejohann, L; Dere, E; de Souza Silva, MA; Herring, A; Keyvani, K; Paulus, W; Schäbitz, WR (2009): Levodopa ameliorates learning and memory deficits in a murine model of Alzheimer's disease. Neurobiology of Aging 30: 1192-1204.
  
  

• Diederich, K; Sevimli, S; Dörr, H; Kösters, E; Hoppen, M; Lewejohann, L; Klocke, R; Minnerup, J; Knecht, S; Nikol, S; Sachser, N; Schneider, A; Gorji, A; Sommer, C; Schäbitz, WR (2009): The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: A characterization of G-CSF deficient mice. The Journal of Neuroscience 29: 11672-11581.
  
  

• Heiming, RS; Jansen, F; Lewejohann, L; Kaiser, S; Schmitt, A; Lesch, KP; Sachser, N (2009): Living in a dangerous world: the shaping of behavioral profile by early environment and 5-HTT genotype. Frontiers in Behavioral Neuroscience 3: 26.
  
  

• Lewejohann, L; Damm, OS; Luetjens, CM; Hämäläinen, T; Simoni, M; Nieschlag, E; Gromoll, J; Wistuba, J (2009): Impaired recognition memory in male mice with a supernumerary X chromosome. Physiology & Behavior 96: 22-29.
  
  

• Lewejohann, L; Hoppmann, AM; Kegel, P; Kritzler, M; Krüger, T; Sachser, N (2009): Behavioral phenotyping of a murine model of Alzheimer's disease in a semi-naturalistic environment using RFID tracking. Behavior Research Methods 41: 850-856.
  
  

• Lewejohann, L; Reefmann, N; Widmann, P; Ambrée, O; Herring, A; Keyvani, K; Paulus, W; Sachser, N (2009): Transgenic Alzheimer mice in a semi-naturalistic environment: More plaques, yet not compromised in daily life. Behavioural Brain Research 201: 99-102.
  
  

• Bacher, M; Dodel, R; Aljabari, B; Keyvani, K; Marambaud, P; Kayed, R; Glabe, C; Görtz, N; Hoppmann, A; Sachser, N; Klotsche, J; Schnell, S; Lewejohann, L; Al-Abed, Y (2008): CNI-1493 inhibits Aß production, plaque formation, and cognitive deterioration in an aimal model of Alzheimer’s disease. The Journal of Experimental Medicine 205 (7): 1593-1599.
  
  

• Görtz, N; Lewejohann, L; Tomm, M; Ambrée, O; Keyvani, K; Paulus, W; Sachser, N (2008): Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice. Behavioural Brain Research 191: 43-48.
  
  

• Lewejohann, L (2008): Fill My Datebook: A Software Tool to Generate and Handle Lists of Events. Behavior Research Methods 40 (2): 391-393.
  
  

• Pallerla, SR; Lawrence, R; Lewejohann, L; Pan, Y; Fischer, T; Schlomann, U; Zhang, X; Esko, JD; Grobe, K (2008): Altered heparan sulfate structure in mice with deleted NDST3 gene function. The Journal of Biological Chemistry 283: 16885-16894.
  
  

• Richter, H; Ambrée, O; Lewejohann, L; Herring, A; Keyvani, K; Paulus, W; Palme, R; Touma, C; Schäbitz WR; Sachser, N (2008): Wheel-running in a transgenic mouse model of Alzheimer’s disease: protection or symptom? Behavioural Brain Research 190: 74-84.
  
  

• Kritzler, M; Lewejohann, L; Krüger (2007): Analysing Movement and Behavioural Patterns of Laboratory Mice in a Semi Natural Environment Based on Data collected via RFID-Technology. In: Gottfried, B (ed.): Workshop on Behaviour Monitoring and Interpretation. Osnabrück.
  
  

• Kritzler, M; Lewejohann, L; Krüger, A; Raubal, M; Sachser, N (2006): An RFID-based tracking system for laboratory mice in a semi-natural environment. In: A. Schmidt, S. Spiekermann, A. Gershman, F. Michahelles (ed.): PTA2006 Workshop, PERVASIVE - pervasive technology applied real-world experiences with RFID and sensor networks. Dublin, Ireland.
  
  

• Lewejohann, L; Reinhard, C; Schrewe, A; Brandewiede, J; Haemisch, A; Görtz, N; Schachner, M; Sachser, N (2006): Environmental Bias? Effects of Housing Conditions, Laboratory Environment, and Experimenter on Behavioral Tests. Genes Brain and Behavior 5: 64-72.
  
  

• Lewejohann, L; Skryabin, BV; Sachser, N; Prehn, C; Heiduschka, P; Thanos, S; Jordan, U; Dell'Omo, G; Vyssotski, AL; Pleskacheva, MG; Lipp, HP; Tiedge, H; Brosius, J; Prior, H (2004): Role of a neuronal small non-messenger RNA: behavioural alterations in BC1 RNA-deleted mice. Behavioural Brain Research 154: 273-289.
  
  

• Touma, C; Ambrée, O; Görtz, N; Keyvani, K; Lewejohann, L; Palme, R; Paulus, W; Schwarze-Eicker, K; Sachser, N (2004): Age- and sex-dependent development of adrenocortical hyperactivity in a transgenic mouse model of Alzheimer's disease. Neurobiology of Aging 25: 893-904.
  
  

• Skryabin, BV; Sukonina, V; Jordan, U; Lewejohann, L; Sachser, N; Muslimov, I; Tiedge, H; Brosius, J (2003): Neuronal untranslated BC1 RNA: targeted gene elimination in mice. Molecular and Cellular Biology 23: 6435-6441.
  
  

• Böckels, C; Lewejohann, L; Sachser, N (2002): Applying elo-rating to assess dominance hierarchiy in male mice. Zoology 105, Supplement V (DZG 95.1): 3.
  
  

• Lewejohann, L (2002): Buchrezension zu Sapolsky, R.M. 'Mein Leben als Pavian'. Spektrum der Wissenschaft 8: 102.
  
  

• Lewejohann, L; Prior, H; Brosius, J; Sachser, N; Skryabin, BV (2002): Behavioural phenotyping of mice lacking BC1, a non-protein coding gene. Zoology 105, Supplement V (DZG 95.1): 3.
  
  

• Lewejohann, L (2001): Buchrezension zu Tembrock, G. 'Angst'. Spektrum der Wissenschaft 9: 95.
  
  

• Lewejohann, L (2001): Was für ein Haus will die Maus? Rodentia 1: 73-75.
  
  

• Lewejohann, L; Edich, I; Sachser, N (2001): Rhythm of activity in closely related inbred strains of mice. Contributions to the XXVII International Ethological Conference, Tübingen, Advances in Ethology 36. Supplements to Ethology: 204.
  
  

• Lewejohann, L; Edich, I; Sachser, N (2001): Circadian rhythm of three closely related inbred strains of mice differing in aggressive behaviour. Zoology 104, Supplement IV (DZG 94.1): 7.
  
  

• Lewejohann, L; Sachser, N (2000): Evaluation of different housing conditions for male laboratory mice. Zoology 103, Supplement III (DZG 93.1): 31.
  
  

• Lewejohann, L; Sachser, N (2000): Präferenztests zur Beurteilung unterschiedlicher Haltungsbedingungen von männlichen Labormäusen. In: Aktuelle Arbeiten zur artgemäßen Tierhaltung 1999. KTBL Schrift 391. Darmstadt: 170-177.
  
  

• Lewejohann, L; Wistuba, J (1999): Mimicry, disappearing acts and imposters. Reptilia (GB) 8: 70-75.
  
  

• Lewejohann, L; Wistuba, J (1997): Guck mal wer da rasselt - 'Geräuschmimikry' bei Schlangen. Reptilia 6: 28-29.
  
  

• Lewejohann, L; Wistuba, J (1997): Mimikry - Tarnkappen und Hochstapler. Reptilia 6: 16-21.